In this episode, we go beyond the famous C. elegans connectome to explore how signal propagation doesn’t always follow the wires. Using powerful whole-brain calcium imaging combined with single-cell optogenetic activation, researchers mapped over 23,000 neuron pairings to build a functional atlas that rewrites parts of the worm’s wiring diagram.

We dive into:

How extrasynaptic neuropeptide signalling connects neurons outside synapses The discovery of functional connections invisible in the wiring diagram How C. elegans neural signals propagate both directly and indirectly The creation of a functional connectome that predicts spontaneous activity better than anatomy alone The surprising flexibility and plasticity of even simple nervous systems

📖 Based on the research article: “Neural signal propagation atlas of Caenorhabditis elegans” Francesco Randi, Anuj K. Sharma, Sophie Dvali & Andrew M. Leifer Published in Nature (2023). 🔗 https://doi.org/10.1038/s41586-023-06683-4

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