Surface Lipids in Nematodes are Influenced by Development and Species-specific Adaptations

This research utilizes 3D-OrbiSIMS to analyze the surface lipids of nematodes, specifically Caenorhabditis elegans and Pristionchus pacificus, revealing their complex chemical compositions. Surface lipids are found to be developmentally dependent and species-specific, highlighting evolutionary adaptations. The study identifies that the peroxisomal β-oxidation pathway, particularly the enzyme DAF-22, is crucial for defining the surface molecular fingerprint and lipid metabolism. Furthermore, altered surface lipid composition in daf-22 mutants increases their susceptibility to predation, demonstrating the role of surface lipids in interspecies interactions and defense mechanisms. These findings enhance our understanding of nematode surface chemistry and its influence on behavior and survival.2025 AM Kotowska, F Hiramatsu, MR Alexander, DJ Scurr, JW Lightfoot, Veeren M Chauhan* “Surface Lipids in Nematodes are Influenced by Development and Species-specific Adaptations” JACShttps://pubs.acs.org/doi/10.1021/jacs.4c12519 This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch.

📩 More info: 🔗 www.veerenchauhan.com 📧 [email protected]