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EPISODE 34: Small Worm, Big Prizes – The Collaboration That Changed Biology
2025-12-03 · 05:00
How does a one-millimetre worm help win four Nobel Prizes? In this episode, we explore how C. elegans became one of the most influential organisms in modern biology — not because of its size, but because of its community. Researchers, beginning with Sydney Brenner’s vision, built an ecosystem of radical openness: shared strains, shared annotations, shared tools, shared knowledge. This culture powered breakthroughs in apoptosis, GFP, RNA interference, and microRNAs, each recognised with a Nobel Prize. We discuss how the CGC, WormBase, WormAtlas, open imaging libraries, and collaborative genetics transformed a tiny worm into a global scientific powerhouse. It’s the story of a field that chose to share — and in doing so, changed biology. Key themes: • The collaborative backbone behind worm research • Why sharing strains and data accelerated Nobel-winning discoveries • How open tools shaped genetics, neuroscience, and ageing research • The social and scientific architecture of a uniquely supportive community • Why C. elegans is still leading modern multi-omics and connectomics Based on the research article:🎧 Subscribe to the WOrM Podcast “From nematode to Nobel: How community-shared resources fueled the rise of Caenorhabditis elegans as a research organism” Victor R. Ambros, Martin Chalfie, Aric L. Daul, Andrew Z. Fire, David H. Hall, H. Robert Horvitz, Craig C. Mello, Gary Ruvkun, Nathan E. Schroeder, Paul W. Sternberg & Ann E. Rougvie. PNAS (2025) 🔗 https://doi.org/10.1073/pnas.2522808122 🎧 Subscribe to the WOrM Podcast Whole-organism stories from molecules to behaviour. This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch. 📩 More info: 🔗 www.veerenchauhan.com 📧 [email protected] |
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SiQun Xu
– guest
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Mary K. Montgomery
– guest
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Veeren Chauhan
– host
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Samuel E. Driver
– guest
,
Andrew Fire
– guest
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Steven A. Kostas
– guest
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Craig C. Mello
– guest
In this episode, we rewind to one of biology’s biggest plot twists: RNA interference (RNAi). Scientists found that injecting double-stranded RNA into Caenorhabditis elegans could silence genes powerfully and precisely—far beyond anything single strands could achieve. This game-changing discovery revealed: How dsRNA triggers targeted gene shutdown Why only a few molecules can silence thousands of cells How gene silencing spreads across tissues The first clues toward RNA-based therapies that would change medicine forever 📖 Based on the research article: “Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans” Andrew Fire, SiQun Xu, Mary K. Montgomery, Steven A. Kostas, Samuel E. Driver & Craig C. Mello. Published in Nature (1998). 🔗 https://doi.org/10.1038/35888 🎧 Subscribe to the WoRM Podcast for more whole-organism stories that changed the world! This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch. 📩 More info: 🔗 www.veerenchauhan.com 📧 [email protected] |
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