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EPISODE 34: Small Worm, Big Prizes – The Collaboration That Changed Biology
2025-12-03 · 05:00
How does a one-millimetre worm help win four Nobel Prizes? In this episode, we explore how C. elegans became one of the most influential organisms in modern biology — not because of its size, but because of its community. Researchers, beginning with Sydney Brenner’s vision, built an ecosystem of radical openness: shared strains, shared annotations, shared tools, shared knowledge. This culture powered breakthroughs in apoptosis, GFP, RNA interference, and microRNAs, each recognised with a Nobel Prize. We discuss how the CGC, WormBase, WormAtlas, open imaging libraries, and collaborative genetics transformed a tiny worm into a global scientific powerhouse. It’s the story of a field that chose to share — and in doing so, changed biology. Key themes: • The collaborative backbone behind worm research • Why sharing strains and data accelerated Nobel-winning discoveries • How open tools shaped genetics, neuroscience, and ageing research • The social and scientific architecture of a uniquely supportive community • Why C. elegans is still leading modern multi-omics and connectomics Based on the research article:🎧 Subscribe to the WOrM Podcast “From nematode to Nobel: How community-shared resources fueled the rise of Caenorhabditis elegans as a research organism” Victor R. Ambros, Martin Chalfie, Aric L. Daul, Andrew Z. Fire, David H. Hall, H. Robert Horvitz, Craig C. Mello, Gary Ruvkun, Nathan E. Schroeder, Paul W. Sternberg & Ann E. Rougvie. PNAS (2025) 🔗 https://doi.org/10.1073/pnas.2522808122 🎧 Subscribe to the WOrM Podcast Whole-organism stories from molecules to behaviour. This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch. 📩 More info: 🔗 www.veerenchauhan.com 📧 [email protected] |
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Dipon Ghosh
– guest
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Dongyeop Lee
– guest
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H. Robert Horvitz
– guest
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Michael N. Nitabach
– guest
,
Xin Jin
– guest
,
Veeren Chauhan
– host
Worms without eyes shouldn’t see colour — yet C. elegans can. In this episode, we dive into a landmark study that shows how worms use blue-to-amber light ratios to make foraging decisions. When exposed to toxic blue pigments like pyocyanin, worms avoid them — but only under white light. The twist? They do it all without opsins. We explore: How worms detect and avoid blue-pigment-secreting P. aeruginosa Why light potentiates avoidance, but only for certain spectral ratios How lite-1 and GUR-3 receptors mediate spectral sensitivity Natural variation in colour preference across wild strains The discovery that stress-related genes jkk-1 and lec-3 underlie colour-guided behaviour This episode uncovers a new form of opsin-free colour vision, expanding our understanding of how simple organisms read complex environments. 📖 Based on the research article: “C. elegans discriminates colors to guide foraging” Dipon Ghosh, Dongyeop Lee, Xin Jin, H. Robert Horvitz & Michael N. Nitabach Published in Science (2021) 🔗 https://doi.org/10.1126/science.abd3010 🎧 Subscribe to the WOrM Podcast for more full-organism surprises in perception, evolution, and behaviour. This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch. 📩 More info: 🔗 www.veerenchauhan.com 📧 [email protected] |
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