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Larry Coyne

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Alexander Gloy

Editor At Large · Fair Observer

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Carsten Larsen

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Title & Speakers Event
EPISODE 25: Heavy Worms, Light Data – Proteomics Gets Personal in C. elegans 2025-08-20
Larsen – guest , Pultz – guest , Giessing – guest , Færgeman – guest , Fredens – guest , Engholm-Keller – guest , Veeren Chauhan – host , Møller-Jensen – guest , Højrup – guest

In this episode, we dive into a milestone in C. elegans systems biology — the first application of SILAC-style metabolic proteome labelling in a whole animal. By feeding worms lysine auxotroph E. coli labelled with heavy lysine (Lys8), researchers enabled quantitative proteomics with precision typically reserved for cell culture.

But it gets better — they made it RNAi compatible, allowing side-by-side comparisons of wild-type vs mutant proteomes in the same run.

We discuss:

How worms were labelled with heavy lysine using auxotrophic E. coli How this enabled 94–97% incorporation of label in just one generation The creation of RNAi-ready NJF01 bacteria for knockdown and labelling Case study: NHR-49 loss alters lipid metabolism proteins at scale Why this approach paves the way for whole-organism proteogenomics

📖 Based on the research article: “Quantitative proteomics by amino acid labeling in C. elegans” Fredens, J., Engholm-Keller, K., Giessing, A., Pultz, D., Larsen, M.R., Højrup, P., Møller-Jensen, J., & Færgeman, N.J. Published in Nature Methods (2011) 🔗 https://doi.org/10.1038/nmeth.1675

🎧 Subscribe to the WOrM Podcast for more full-organism breakthroughs in metabolism, proteomics, and systems biology!

This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch.

📩 More info: 🔗 ⁠⁠www.veerenchauhan.com⁠⁠ 📧 [email protected]

AI/ML
WOrM Podcast: Whole Organism Analytics Podcast
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Databricks MosaicX Spotlight Meetup 2024-05-22 · 22:00

Please register at the official page here: https://events.databricks.com/FY250522-EV-MosaicSpotlightMeetup-NYC

MosaicX Spotlight is a technical meetup series that focuses on applying the latest GenAI research to business use cases. MosaicX Spotlight NYC will be held at The Times Center, and feature researchers and engineers from Databricks, Databricks Mosaic Research, AI Squared, Patronus AI, Osmo AI, and more! For those who would like to discuss the business around GenAI, we will also be joined by Inspired Capital. Join us as we discuss the research, technologies, and techniques behind how we built DBRX, a leading open-source LLM built completely on Databricks. In addition to discussing how we built it, we've invited key GenAI leaders from the NYC area so we can discuss various aspects of GenAI from performance to reliability. Note that the formalized agenda will be available on May 6th.

Lightning Talks

Panel Discussions

We will have panel discussions around the research and business of Generative AI featuring:

This is a first come, first serve catered event with a capacity for 300 people so please sign up before tickets run out.

 Databricks MosaicX Spotlight Meetup
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