Search – talk-data.com

Title & Speakers	Event
EPISODE 15: Silent but Deadly – How RNAi Changed Worms (and Science) 2025-05-28 SiQun Xu – guest , Mary K. Montgomery – guest , Veeren Chauhan – host , Samuel E. Driver – guest , Andrew Fire – guest , Steven A. Kostas – guest , Craig C. Mello – guest In this episode, we rewind to one of biology’s biggest plot twists: RNA interference (RNAi). Scientists found that injecting double-stranded RNA into Caenorhabditis elegans could silence genes powerfully and precisely—far beyond anything single strands could achieve. This game-changing discovery revealed: How dsRNA triggers targeted gene shutdown Why only a few molecules can silence thousands of cells How gene silencing spreads across tissues The first clues toward RNA-based therapies that would change medicine forever 📖 Based on the research article: “Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans” Andrew Fire, SiQun Xu, Mary K. Montgomery, Steven A. Kostas, Samuel E. Driver & Craig C. Mello. Published in Nature (1998). 🔗 https://doi.org/10.1038/35888 🎧 Subscribe to the WoRM Podcast for more whole-organism stories that changed the world! This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch. 📩 More info: 🔗 ⁠www.veerenchauhan.com⁠ 📧 [email protected] AI/ML	WOrM Podcast: Whole Organism Analytics Podcast Listen

In this episode, we rewind to one of biology’s biggest plot twists: RNA interference (RNAi). Scientists found that injecting double-stranded RNA into Caenorhabditis elegans could silence genes powerfully and precisely—far beyond anything single strands could achieve.

This game-changing discovery revealed:

How dsRNA triggers targeted gene shutdown Why only a few molecules can silence thousands of cells How gene silencing spreads across tissues The first clues toward RNA-based therapies that would change medicine forever

📖 Based on the research article: “Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans” Andrew Fire, SiQun Xu, Mary K. Montgomery, Steven A. Kostas, Samuel E. Driver & Craig C. Mello. Published in Nature (1998). 🔗 https://doi.org/10.1038/35888

🎧 Subscribe to the WoRM Podcast for more whole-organism stories that changed the world!

This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch.

📩 More info: 🔗 ⁠www.veerenchauhan.com⁠ 📧 [email protected]

talk-data.com

People (9 results)

Activities & events