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How can a worm’s intestine influence its descendants’ lifespan? This episode explores how lysosomes send metabolic signals through the epigenome to extend longevity across generations.

Researchers found that activating lysosomal lipid metabolism triggers transcriptional up-regulation of a histone variant, H3.3 (his-71), in the intestine. This histone is transported to the germ line, where it’s methylated at K79 by the methyltransferase DOT-1.3. The result is a heritable epigenetic state that promotes longer life across multiple generations of C. elegans.

The work reveals how metabolic signalling through lysosomes interacts with chromatin to link soma and germ line, showing how environmental changes like starvation can shape longevity inheritance.

📖 Based on: Zhang Q., Dang W., Wang M.C. Science (2025). “Lysosomes signal through the epigenome to regulate longevity across generations.” https://doi.org/10.1126/science.adn8754

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This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch.

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Please RSVP here on Luma.

5:30pm - Networking 6:00pm - TechXChange Dev Day Meetup - Open Source AI in NYC for Developers ​ Agenda will/may include as many as possible of these talks and demos

• ​Granite - Open Source Models - BJ Hargrave & Ming Zhang
• ​Docling - Document processing\, parsing diverse formats - Michele Dolfi
• ​LM Studio - Your local AI toolkit & bringing it all together - Yagil Burowski
• ​Bee AI - Discover\, run\, and compose AI agents from any framework - Shereen Bellamy and Eden Gilbert
• ​LocalStack - Develop and test your AI-powered cloud apps locally - Waldemar Hummer
• ​Panel for Q&A

​7:30pm - Networking

To attend: Please enroll here https://lu.ma/muqvquop

5:30pm - Networking 6:00pm - TechXChange Dev Day Meetup - Open Source AI in NYC for Developers​ Agenda will/may include as many as possible of these talks and demos ​Granite - Open Source Models - BJ Hargrave & Ming Zhang ​Docling - Document processing\, parsing diverse formats - Michele Dolfi ​LM Studio - Your local AI toolkit & bringing it all together - Yagil Burowski ​Bee AI - Discover\, run\, and compose AI agents from any framework - Shereen Bellamy ​LocalStack - Develop and test your AI-powered cloud apps locally - Waldemar Hummer ​Panel for Q&A ​7:30pm - Networking