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Tracking drug delivery inside cells is a challenge when the drug carrier itself is invisible. In this episode, we discuss a breakthrough in polymer science: the creation of fluorescent poly(lactic-co-glycolic acid) (PLGA) nanoparticles using a one-step, solvent-free dye-initiated polymerisation process. By covalently attaching dyes (blue, green, or red) to every PLGA chain, these nanoparticles become intrinsically fluorescent—meaning their position can be accurately tracked inside cells and tissues, without the risk of dye leakage. This study shows how these fluorescent PLGA nanoparticles behave in: Human THP-1 macrophages, where they were tracked using super-resolution microscopy.Live Caenorhabditis elegans, where their journey through the digestive tract was mapped.Drug delivery experiments, where the release of the anticancer drug doxorubicin was simultaneously tracked alongside the polymer carrier.This innovation offers a powerful new tool for researchers studying drug delivery, vaccine carriers, and polymer biodistribution. 📖 Based on the research article:"Facile Dye-Initiated Polymerization of Lactide–Glycolide Generates Highly Fluorescent Poly(lactic-co-glycolic Acid) for Enhanced Characterization of Cellular Delivery"Mohammad A. Al-Natour, Mohamed D. Yousif, Robert Cavanagh, Amjad Abouselo, Edward A. Apebende, Amir Ghaemmaghami, Dong-Hyun Kim, Jonathan W. Aylott, Vincenzo Taresco, Veeren M. Chauhan & Cameron Alexander. Published in ACS Macro Letters (2020).🔗 Read the full paper 🎧 Subscribe to the WoRM Podcast for more discoveries at the interface of polymers, drug delivery, and whole-organism research! This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch.

📩 More info: 🔗 www.veerenchauhan.com 📧 [email protected]

Le Green Data for Health (GD4H), initiative du Commissariat général au développement durable (CGDD), et le Health Data Hub (HDH) ont le plaisir de vous convier le 17 juin, de 14h30 à 18h à PariSanté Campus, pour un après-midi consacré aux enjeux et défis soulevés par le croisement des données environnementales et de santé.

Attention, l’inscription se fait UNIQUEMENT via l’un de ces deux liens : Lien inscription présentiel Lien inscription distanciel

Vous pouvez aussi consulter notre page dédiée.

AU PROGRAMME :

14h30 - 15h : Introduction : Quels enjeux numériques dans le cadre du PNSE4 ? Ministère de la Transition écologique et de la Cohésion des territoires Health Data Hub

15h - 15h30 : Présentation de deux cas d’usage de l’utilisation des données en santé-environnement au profit de l’amélioration de la connaissance scientifique

• 1. Présentation du projet “MRC-PE (Maladie Rénale Chronique - Profils Environnementaux)”

Michaël Genin, Maître de conférences et praticien hospitalier en biostatistique au CHU de Lille

• 2. Présentation du projet “Jumeaux Numérique : État de santé d’un territoire”

Sylvie Kermabon, Directrice de projet au Groupe VYV

15h30 - 16h30 : Regards croisés sur “Mieux connaître pour agir : santé, climat et prévention” Robert Barouki, Responsable de l’unité de recherche “Pharmacologie, toxicologie et signalisation cellulaire” de l'Inserm Raymond Cointe, Directeur général de l'Ineris Sébastien Denys, Directeur Santé-Environnement-Travail à Santé publique France Florie Fillol, Responsable projets prévention et accompagnement de projets innovants en santé à l’AIS

16h30 - 16h40 : Présentation de l’appel à projets “La donnée au service de la recherche et de l’innovation en santé-environnement” Marie Ramon-Dare, Adjointe au chef de bureau Innovation DATA/IA de Green Data for Health (CGDD) Maxime Caillet, Coordinateur à la Direction des Partenariats du Health Data Hub (HDH)

16h40 - 17h30 : Annonce des lauréats du second appel à projets “La donnée en santé-environnement au service de la recherche et de l’innovation” François Hissel, Directeur de la surveillance, de l'évaluation et des données à l’Office français de la biodiversité (OFB) Sébastien Lesterle, Chargé de mission santé environnement à la sous-direction Prévention des risques liés à l’environnement et à l’alimentation de la DGS

17h30 : Cocktail de clôture

Nous nous réjouissons de vous retrouver à PariSanté Campus, ou en ligne !

Join us on Tuesday 12 March for our 12th OpenUK London community meetup! Last year saw the rise of Generative AI. So many of those projects are based on open source software and open data. What have you been building? What open source tools have been helping you be more productive?

6:30 pm: Arrive, grab a bev, a slice and a chat. Scope out our swag table (bring giveaways to contribute or trade!)

7:00 pm: It's demo time! Show us what you've built or contributed to or just open source projects related to AI that you just love! We'd love to get people signed up ahead if you'd like to message Jen. So far, we expect:

• Robert Castelo demoing some new AI features for Drupal
• Bettina Moltrecht, PhD, demoing Harmony NLP for Mental Health Data
• Someone demoing AI features developed by the Green Software Foundation
• Kyle Luster and Fábio Santos sharing how to apply a Large Language Models API to Issue Classification Problem (remote presenter)
• Zixuan (Steve) Feng will share a new OSS community retention management system that integrates AI and statistical models (remote presenter)
• Jacob Penney and Fábio Santos will talk about the prototype GiveMeLabeledIssues

More to come including... maybe YOU?

8:15-8:30 pm: Cleanup and see-ya-next-time.

Please remember to bring your I.D. if you are attending in person, as it is required to access the venue. Note the venue does not permit e-scooters or bicycles within the building.

Thank you to our sponsors Avanade for providing this great space and pizza! By attending this or any OpenUK event, you are adhering to our Code of Respect and OpenUK's Competition Policy. Please read ahead.

If you would like to hear more about OpenUK's other events, you can join our Newsletter. After the event, look out for a Meetup message with an invite to our burgeoning Slack community as a way to keep in touch and support each other between activities.

Hey there, data enthusiasts and ClickHouse aficionados! We've got some exciting news to share - our next meetup is on the horizon, and it's going to be an epic data-driven shindig!

Get ready for a delightful mix of mind-boggling data tales, insightful conversations, and maybe even a surprise or two up our sleeves.

But here's the deal: to secure your spot, make sure you register ASAP!

Agenda:

1800 - 1830

• Networking with drinks & snacks

1830 - 1900

• MySQL Wire Protocol - Robert Schulze & Serge Klochkov

1900 - 1930

• Workload Scheduling - Sergei Trifonov

1930 - 2000

• It’s a SURPRISE! (perhaps even a special one)

2000 - 2100

• Food & Networking

• (Homemade Melanzane alla Parmigiana from slow-cooked aubergines, tomatoes and Dutch sheep's cheese, a lightly filled green salad with herbs and cresses and handmade bread with salted butter.)

If you are interested in speaking, please contact [email protected]