talk-data.com
People (48 results)
See all 48 →Activities & events
| Title & Speakers | Event |
|---|---|
|
EPISODE 34: Small Worm, Big Prizes – The Collaboration That Changed Biology
2025-12-03 · 05:00
How does a one-millimetre worm help win four Nobel Prizes? In this episode, we explore how C. elegans became one of the most influential organisms in modern biology — not because of its size, but because of its community. Researchers, beginning with Sydney Brenner’s vision, built an ecosystem of radical openness: shared strains, shared annotations, shared tools, shared knowledge. This culture powered breakthroughs in apoptosis, GFP, RNA interference, and microRNAs, each recognised with a Nobel Prize. We discuss how the CGC, WormBase, WormAtlas, open imaging libraries, and collaborative genetics transformed a tiny worm into a global scientific powerhouse. It’s the story of a field that chose to share — and in doing so, changed biology. Key themes: • The collaborative backbone behind worm research • Why sharing strains and data accelerated Nobel-winning discoveries • How open tools shaped genetics, neuroscience, and ageing research • The social and scientific architecture of a uniquely supportive community • Why C. elegans is still leading modern multi-omics and connectomics Based on the research article:🎧 Subscribe to the WOrM Podcast “From nematode to Nobel: How community-shared resources fueled the rise of Caenorhabditis elegans as a research organism” Victor R. Ambros, Martin Chalfie, Aric L. Daul, Andrew Z. Fire, David H. Hall, H. Robert Horvitz, Craig C. Mello, Gary Ruvkun, Nathan E. Schroeder, Paul W. Sternberg & Ann E. Rougvie. PNAS (2025) 🔗 https://doi.org/10.1073/pnas.2522808122 🎧 Subscribe to the WOrM Podcast Whole-organism stories from molecules to behaviour. This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch. 📩 More info: 🔗 www.veerenchauhan.com 📧 [email protected] |
|
|
Rhonda L. Feinbaum
– guest
,
Rosalind C. Lee
– guest
,
Victor Ambros
– guest
,
Veeren Chauhan
– host
In this episode, we travel back to one of the great origin stories in gene regulation: the discovery of lin-4, the first-ever microRNA. In Caenorhabditis elegans, scientists found that tiny non-coding RNAs could silence gene expression by pairing with target mRNAs — launching the entire field of microRNA biology. We explore: How lin-4 regulates developmental timing by repressing LIN-14 protein The discovery of small RNAs (22 and 61 nucleotides) as gene regulators The first evidence for RNA-RNA antisense interactions controlling translation Why this work reshaped our understanding of gene expression across species How a worm taught us that not all genes code for proteins 📖 Based on the research article: "The C. elegans Heterochronic Gene lin-4 Encodes Small RNAs with Antisense Complementarity to lin-14" Rosalind C. Lee, Rhonda L. Feinbaum & Victor Ambros. Published in Cell (1993). 🔗 https://doi.org/10.1016/0092-8674(93)90529-Y 🎧 Subscribe to the WOrM Podcast for more whole-organism breakthroughs that reshaped biology! This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch. 📩 More info: 🔗 www.veerenchauhan.com 📧 [email protected] |
|