AI has the potential to transform learning, work, and daily life for millions of people, but only if we design with accessibility at the core. Too often, disabled people are underrepresented in datasets, creating systemic barriers that ripple through models and applications. This talk explores how data scientists and technologists can mitigate bias, from building synthetic datasets to fine-tuning LLMs on accessibility-focused corpora. We’ll look at opportunities in multimodal AI: voice, gesture, AR/VR, and even brain-computer interfaces, that open new pathways for inclusion. Beyond accuracy, we’ll discuss evaluation metrics that measure usability, comprehension, and inclusion, and why testing with humans is essential to closing the gap between model performance and lived experience. Attendees will leave with three tangible ways to integrate accessibility into their own work through datasets, open-source tools, and collaborations. Accessibility is not just an ethical mandate, it’s a driver of innovation, and it begins with thoughtful, human-centered data science.