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Title & Speakers	Event
Event WOrM Podcast: Whole Organism Analytics Podcast 2025-10-22
EPISODE 32: Colour Code – Smart Polymers That Glow, Track, and Heal 2025-10-22 · 04:05 Vincenzo Taresco – guest , Nana A. Berfi – guest , Veeren M Chauhan – curator/researcher @ University of Nottingham , Benedetta Brugnoli – guest , Philippa L. Jacob – guest , Benoit Couturaud – guest , Lei Lei – guest , Iolanda Francolini – guest , Eleni Axioti – guest , Robert J. Cavanagh – guest , Luciano Galantini – guest How do you make a nanoparticle that tells you where it is and helps at the same time? In this episode, we dive into the chemistry behind polydiacetylene (PDA)—a polymer that changes colour when it senses temperature, pH, or stress. Researchers combined PDA with biodegradable poly(glycerol adipate) to create self-reporting nanoparticles that: Change colour from blue to red under stress or heat Track cells and nematodes without any added fluorescent dyes Degrade naturally via enzymatic action Carry drugs like usnic acid for therapeutic delivery It’s a step toward theranostic polymers—materials that diagnose and treat simultaneously, glowing as they go. Even C. elegans joined the test, confirming safe uptake and real-time visibility. 📖 Based on the research article: “Tailoring the Properties of Polydiacetylene Nanosystems for Enhanced Cell Tracking Through Poly(glycerol Adipate) Blending: an In Vitro and In Vivo Investigation” Benedetta Brugnoli, Eleni Axioti, Philippa L. Jacob, Nana A. Berfi, Lei Lei, Benoit Couturaud, Veeren M. Chauhan, Robert J. Cavanagh, Luciano Galantini, Iolanda Francolini & Vincenzo Taresco Published in Macromolecular Chemistry and Physics (2025) 🔗 https://doi.org/10.1002/macp.202500259 🎧 Subscribe to the WOrM Podcast for more bright ideas in molecular sensing, smart polymers, and organism-level science. This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch. 📩 More info: 🔗 ⁠⁠www.veerenchauhan.com⁠⁠ 📧 [email protected] AI/ML	Listen
EPISODE 9: Divergent Diets, Divergent Defences – Intestinal Evolution in C. elegans and P. pacificus 2025-04-16 Veeren M Chauhan – curator/researcher @ University of Nottingham , Christian Rödelsperger – guest , Jonathan W. Aylott – guest , James W. Lightfoot – guest How does a nematode’s feeding strategy shape its gut biology and disease resistance? In this episode, we explore a comparative gut transcriptomics study of Caenorhabditis elegans and Pristionchus pacificus that reveals how changes in anatomy and lifestyle have led to major shifts in gene expression and pathogen susceptibility. We discuss: Why P. pacificus lacks the grinder structure and how this changes its digestion What makes their intestinal gene expression profiles so divergent, despite being close relatives The role of Hedgehog signalling and lineage-specific genes in intestinal development Surprising findings on gut pH stability despite transcriptomic divergence How these factors shape resistance to pathogens and environmental adaptation 📖 Based on the research article: “Comparative transcriptomics of the nematode gut identifies global shifts in feeding mode and pathogen susceptibility” James W. Lightfoot, Veeren M. Chauhan, Jonathan W. Aylott & Christian Rödelsperger. Published in BMC Research Notes (2016). 🔗 https://doi.org/10.1186/s13104-016-1886-9 🎧 Subscribe to the WoRM Podcast for more on nematode evolution, gut biology, and systems-level research. This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch. 📩 More info: 🔗 ⁠www.veerenchauhan.com⁠ 📧 [email protected] AI/ML	Listen
EPISODE 7: Bright Polymers – Tracking Drug Delivery with Fluorescent PLGA Nanoparticles 2025-04-02 Vincenzo Taresco – guest , Veeren M Chauhan – curator/researcher @ University of Nottingham , Jonathan W. Aylott – guest , Amir Ghaemmaghami – guest , Mohamed D. Yousif – guest , Amjad Abouselo – guest , Dong-Hyun Kim – guest , Edward A. Apebende – guest , Mohammad A. Al-Natour – guest , Robert Cavanagh – guest , Cameron Alexander – guest Tracking drug delivery inside cells is a challenge when the drug carrier itself is invisible. In this episode, we discuss a breakthrough in polymer science: the creation of fluorescent poly(lactic-co-glycolic acid) (PLGA) nanoparticles using a one-step, solvent-free dye-initiated polymerisation process. By covalently attaching dyes (blue, green, or red) to every PLGA chain, these nanoparticles become intrinsically fluorescent—meaning their position can be accurately tracked inside cells and tissues, without the risk of dye leakage. This study shows how these fluorescent PLGA nanoparticles behave in: Human THP-1 macrophages, where they were tracked using super-resolution microscopy.Live Caenorhabditis elegans, where their journey through the digestive tract was mapped.Drug delivery experiments, where the release of the anticancer drug doxorubicin was simultaneously tracked alongside the polymer carrier.This innovation offers a powerful new tool for researchers studying drug delivery, vaccine carriers, and polymer biodistribution. 📖 Based on the research article:"Facile Dye-Initiated Polymerization of Lactide–Glycolide Generates Highly Fluorescent Poly(lactic-co-glycolic Acid) for Enhanced Characterization of Cellular Delivery"Mohammad A. Al-Natour, Mohamed D. Yousif, Robert Cavanagh, Amjad Abouselo, Edward A. Apebende, Amir Ghaemmaghami, Dong-Hyun Kim, Jonathan W. Aylott, Vincenzo Taresco, Veeren M. Chauhan & Cameron Alexander. Published in ACS Macro Letters (2020).🔗 Read the full paper 🎧 Subscribe to the WoRM Podcast for more discoveries at the interface of polymers, drug delivery, and whole-organism research! This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch. 📩 More info: 🔗 www.veerenchauhan.com 📧 [email protected] AI/ML	Listen
EPISODE 6: Bloodthirsty Worms – Haematophagic Caenorhabditis elegans and Vaccine Discovery 2025-03-26 · 01:00 David I. Pritchard – guest , Veeren M Chauhan – curator/researcher @ University of Nottingham Can a normally bacteria-feeding nematode become a blood-feeder? In this episode, we dive into the surprising world of haematophagic Caenorhabditis elegans — worms that can consume human blood. This research explores how feeding C. elegans a diet of erythrocytes (red blood cells) could help accelerate vaccine development for parasitic infections like hookworm disease. By studying the enzymes used by these worms to digest haemoglobin and detoxify haem, scientists are unlocking new ways to test anti-parasite vaccines — all without needing live hookworms. 🔍 Key Topics Covered: • How C. elegans can ingest and survive on a diet of human blood • Using fluorescently labelled red blood cells to track feeding behaviour • Comparing digestive enzymes of C. elegans to those of Necator americanus, a major human parasite • Why this breakthrough could help identify and test new vaccine candidates 📖 Based on the research article: “Haematophagic Caenorhabditis elegans” Veeren M. Chauhan & David I. Pritchard. Published in Parasitology (2019). 🔗 Read it here: https://doi.org/10.1017/S0031182018001518 Join us to discover how turning a free-living nematode into a blood-feeder could reshape vaccine research for parasitic diseases! 🎧 Subscribe to the WoRM Podcast for more surprising stories at the intersection of parasitology, biotechnology, and innovation. This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch. 📩 More info: 🔗 www.veerenchauhan.com 📧 [email protected] AI/ML	Listen
EPISODE 5: Unlocking the Physicochemical Fingerprint of the Hookworm Necator americanus 2025-03-19 · 01:00 David I. Pritchard – guest , Veeren M Chauhan – curator/researcher @ University of Nottingham , David J. Scurr – guest , Jonathan W. Aylott – guest , Gary Telford – guest , Thomas Christie – guest How does a tiny hookworm outsmart the human immune system? In this episode, we explore the physicochemical fingerprint of Necator americanus, a parasite that infects millions worldwide. Using cutting-edge techniques like atomic force microscopy (AFM) and time-of-flight secondary ion mass spectrometry (ToF-SIMS), researchers reveal how the hookworm’s sheath and cuticle surfaces play a crucial role in immune evasion and infection. 🔍 Key Topics Covered: • The unique surface properties of N. americanus at the infective L3 stage • How the hookworm’s sheath diverts immune defences, aiding reinfection • The role of nano-annuli in enhancing adhesion and survival • How surface chemistry, including heparan sulphate and phosphatidylglycerol, influences parasite migration 📖 Based on the research article: “The Physicochemical Fingerprint of Necator americanus”** Veeren M. Chauhan, David J. Scurr, Thomas Christie, Gary Telford, Jonathan W. Aylott, David I. Pritchard. Published in PLOS Neglected Tropical Diseases (2017). 🔗 Read it here: https://doi.org/10.1371/journal.pntd.0005971 Join us as we discuss how surface biochemistry influences parasite survival, reinfection, and potential future treatments! 🎧 Subscribe to the WoRM Podcast for more deep dives into cutting-edge parasitology research! This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch. 📩 More info: 🔗 www.veerenchauhan.com 📧 [email protected] AI/ML	Listen
EPISODE 4: Magic Nanosensors Reveal Intestinal pH Oscillations in C. elegans 2025-03-12 · 01:00 David I. Pritchard – guest , Veeren M Chauhan – curator/researcher @ University of Nottingham , Jonathan W. Aylott – guest , Alan Brown – guest , Gianni Orsi – guest Did you know that digestion in C. elegans follows a rhythmic pH cycle? In this episode, we explore how magic nanosensors uncover real-time intestinal pH oscillations inside these tiny nematodes. By mapping the gut’s acidic landscape, researchers reveal how proton pumps, digestion, and metabolism work together in a synchronised chemical dance—offering new insights for biomedicine and drug discovery. 🔍 Key Topics Covered: • How pH-sensitive nanosensors track acidity in living organisms • The real-time pH oscillations inside the C. elegans gut • The role of proton pumps and metabolism in digestion • How this discovery could impact gut health and biomedical research 📖 Based on the research article: “Mapping the Pharyngeal and Intestinal pH of Caenorhabditis elegans and Real-Time Luminal pH Oscillations Using Extended Dynamic Range pH-Sensitive Nanosensors” Veeren M. Chauhan, Gianni Orsi, Alan Brown, David I. Pritchard, Jonathan W. Aylott. Published in ACS Nano (2013). 🔗 Read it here: https://doi.org/10.1021/nn401856u Join us as we uncover how pH-shifting nanosensors are revolutionising our understanding of digestion and metabolism! 🎧 Subscribe to the WoRM Podcast for more deep dives into frontier science! This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch. 📩 More info: 🔗 www.veerenchauhan.com 📧 [email protected] AI/ML	Listen
EPISODE 3: The Hidden Mechanical Properties of Biological Surfaces – Brillouin Endo-Microscopy 2025-03-05 · 01:00 Veeren M Chauhan – curator/researcher @ University of Nottingham , Salvatore La Cavera III – guest In this episode, we uncover a revolutionary approach to imaging the hidden mechanical properties of biological surfaces using Label-Free Brillouin Endo-Microscopy. Unlike traditional imaging techniques that rely on fluorescent labels, this method provides quantitative 3D viscoelastic mapping at the sub-micrometre scale—offering unprecedented insights into biological structures. 🔍 Key Topics Covered: • How Brillouin scattering enables real-time mechanical imaging of living tissue • First-ever 3D stiffness mapping of Caenorhabditis elegans cuticle in situ • Potential applications for non-invasive diagnostics and disease research • The future of elasticity-based biomedical imaging 📖 Based on the research article: “Label-Free Brillouin Endo-Microscopy for the Quantitative 3D Imaging of Sub-Micrometre Biology” Salvatore La Cavera III, Veeren M. Chauhan, et al. Published in Communications Biology (2024). 🔗 Read it here: https://doi.org/10.1038/s42003-024-06126-4 Join us as we explore how this breakthrough could transform biomedical imaging, mechanobiology, and in vivo diagnostics! 🎧 Subscribe to the WoRM Podcast for more deep dives into groundbreaking research! This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch. 📩 More info: 🔗 www.veerenchauhan.com 📧 [email protected] AI/ML	Listen
EPISODE 1: Nematode Surface Lipids: Development, Species Adaptations, and Interactions 2025-02-21 · 11:32 Veeren M Chauhan – curator/researcher @ University of Nottingham Surface Lipids in Nematodes are Influenced by Development and Species-specific Adaptations This research utilizes 3D-OrbiSIMS to analyze the surface lipids of nematodes, specifically Caenorhabditis elegans and Pristionchus pacificus, revealing their complex chemical compositions. Surface lipids are found to be developmentally dependent and species-specific, highlighting evolutionary adaptations. The study identifies that the peroxisomal β-oxidation pathway, particularly the enzyme DAF-22, is crucial for defining the surface molecular fingerprint and lipid metabolism. Furthermore, altered surface lipid composition in daf-22 mutants increases their susceptibility to predation, demonstrating the role of surface lipids in interspecies interactions and defense mechanisms. These findings enhance our understanding of nematode surface chemistry and its influence on behavior and survival.2025 AM Kotowska, F Hiramatsu, MR Alexander, DJ Scurr, JW Lightfoot, Veeren M Chauhan* “Surface Lipids in Nematodes are Influenced by Development and Species-specific Adaptations” JACShttps://pubs.acs.org/doi/10.1021/jacs.4c12519 This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch. 📩 More info: 🔗 www.veerenchauhan.com 📧 [email protected] AI/ML	Listen

EPISODE 32: Colour Code – Smart Polymers That Glow, Track, and Heal 2025-10-22 · 04:05

Vincenzo Taresco – guest , Nana A. Berfi – guest , Veeren M Chauhan – curator/researcher @ University of Nottingham , Benedetta Brugnoli – guest , Philippa L. Jacob – guest , Benoit Couturaud – guest , Lei Lei – guest , Iolanda Francolini – guest , Eleni Axioti – guest , Robert J. Cavanagh – guest , Luciano Galantini – guest

How do you make a nanoparticle that tells you where it is and helps at the same time? In this episode, we dive into the chemistry behind polydiacetylene (PDA)—a polymer that changes colour when it senses temperature, pH, or stress.

Researchers combined PDA with biodegradable poly(glycerol adipate) to create self-reporting nanoparticles that:

Change colour from blue to red under stress or heat Track cells and nematodes without any added fluorescent dyes Degrade naturally via enzymatic action Carry drugs like usnic acid for therapeutic delivery

It’s a step toward theranostic polymers—materials that diagnose and treat simultaneously, glowing as they go. Even C. elegans joined the test, confirming safe uptake and real-time visibility.

📖 Based on the research article: “Tailoring the Properties of Polydiacetylene Nanosystems for Enhanced Cell Tracking Through Poly(glycerol Adipate) Blending: an In Vitro and In Vivo Investigation” Benedetta Brugnoli, Eleni Axioti, Philippa L. Jacob, Nana A. Berfi, Lei Lei, Benoit Couturaud, Veeren M. Chauhan, Robert J. Cavanagh, Luciano Galantini, Iolanda Francolini & Vincenzo Taresco Published in Macromolecular Chemistry and Physics (2025) 🔗 https://doi.org/10.1002/macp.202500259

🎧 Subscribe to the WOrM Podcast for more bright ideas in molecular sensing, smart polymers, and organism-level science.

This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch.

📩 More info: 🔗 ⁠⁠www.veerenchauhan.com⁠⁠ 📧 [email protected]

AI/ML

EPISODE 9: Divergent Diets, Divergent Defences – Intestinal Evolution in C. elegans and P. pacificus 2025-04-16

Veeren M Chauhan – curator/researcher @ University of Nottingham , Christian Rödelsperger – guest , Jonathan W. Aylott – guest , James W. Lightfoot – guest

How does a nematode’s feeding strategy shape its gut biology and disease resistance? In this episode, we explore a comparative gut transcriptomics study of Caenorhabditis elegans and Pristionchus pacificus that reveals how changes in anatomy and lifestyle have led to major shifts in gene expression and pathogen susceptibility.

We discuss:

Why P. pacificus lacks the grinder structure and how this changes its digestion What makes their intestinal gene expression profiles so divergent, despite being close relatives The role of Hedgehog signalling and lineage-specific genes in intestinal development Surprising findings on gut pH stability despite transcriptomic divergence How these factors shape resistance to pathogens and environmental adaptation

📖 Based on the research article: “Comparative transcriptomics of the nematode gut identifies global shifts in feeding mode and pathogen susceptibility” James W. Lightfoot, Veeren M. Chauhan, Jonathan W. Aylott & Christian Rödelsperger. Published in BMC Research Notes (2016). 🔗 https://doi.org/10.1186/s13104-016-1886-9

🎧 Subscribe to the WoRM Podcast for more on nematode evolution, gut biology, and systems-level research.

This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch.

📩 More info: 🔗 ⁠www.veerenchauhan.com⁠ 📧 [email protected]

AI/ML

EPISODE 7: Bright Polymers – Tracking Drug Delivery with Fluorescent PLGA Nanoparticles 2025-04-02

Vincenzo Taresco – guest , Veeren M Chauhan – curator/researcher @ University of Nottingham , Jonathan W. Aylott – guest , Amir Ghaemmaghami – guest , Mohamed D. Yousif – guest , Amjad Abouselo – guest , Dong-Hyun Kim – guest , Edward A. Apebende – guest , Mohammad A. Al-Natour – guest , Robert Cavanagh – guest , Cameron Alexander – guest

Tracking drug delivery inside cells is a challenge when the drug carrier itself is invisible. In this episode, we discuss a breakthrough in polymer science: the creation of fluorescent poly(lactic-co-glycolic acid) (PLGA) nanoparticles using a one-step, solvent-free dye-initiated polymerisation process. By covalently attaching dyes (blue, green, or red) to every PLGA chain, these nanoparticles become intrinsically fluorescent—meaning their position can be accurately tracked inside cells and tissues, without the risk of dye leakage. This study shows how these fluorescent PLGA nanoparticles behave in: Human THP-1 macrophages, where they were tracked using super-resolution microscopy.Live Caenorhabditis elegans, where their journey through the digestive tract was mapped.Drug delivery experiments, where the release of the anticancer drug doxorubicin was simultaneously tracked alongside the polymer carrier.This innovation offers a powerful new tool for researchers studying drug delivery, vaccine carriers, and polymer biodistribution. 📖 Based on the research article:"Facile Dye-Initiated Polymerization of Lactide–Glycolide Generates Highly Fluorescent Poly(lactic-co-glycolic Acid) for Enhanced Characterization of Cellular Delivery"Mohammad A. Al-Natour, Mohamed D. Yousif, Robert Cavanagh, Amjad Abouselo, Edward A. Apebende, Amir Ghaemmaghami, Dong-Hyun Kim, Jonathan W. Aylott, Vincenzo Taresco, Veeren M. Chauhan & Cameron Alexander. Published in ACS Macro Letters (2020).🔗 Read the full paper 🎧 Subscribe to the WoRM Podcast for more discoveries at the interface of polymers, drug delivery, and whole-organism research! This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch.

📩 More info: 🔗 www.veerenchauhan.com 📧 [email protected]

AI/ML

EPISODE 6: Bloodthirsty Worms – Haematophagic Caenorhabditis elegans and Vaccine Discovery 2025-03-26 · 01:00

David I. Pritchard – guest , Veeren M Chauhan – curator/researcher @ University of Nottingham

Can a normally bacteria-feeding nematode become a blood-feeder? In this episode, we dive into the surprising world of haematophagic Caenorhabditis elegans — worms that can consume human blood. This research explores how feeding C. elegans a diet of erythrocytes (red blood cells) could help accelerate vaccine development for parasitic infections like hookworm disease.

By studying the enzymes used by these worms to digest haemoglobin and detoxify haem, scientists are unlocking new ways to test anti-parasite vaccines — all without needing live hookworms.

🔍 Key Topics Covered: • How C. elegans can ingest and survive on a diet of human blood • Using fluorescently labelled red blood cells to track feeding behaviour • Comparing digestive enzymes of C. elegans to those of Necator americanus, a major human parasite • Why this breakthrough could help identify and test new vaccine candidates

📖 Based on the research article: “Haematophagic Caenorhabditis elegans” Veeren M. Chauhan & David I. Pritchard. Published in Parasitology (2019). 🔗 Read it here: https://doi.org/10.1017/S0031182018001518

Join us to discover how turning a free-living nematode into a blood-feeder could reshape vaccine research for parasitic diseases!

🎧 Subscribe to the WoRM Podcast for more surprising stories at the intersection of parasitology, biotechnology, and innovation.

This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch.

📩 More info: 🔗 www.veerenchauhan.com 📧 [email protected]

AI/ML

EPISODE 5: Unlocking the Physicochemical Fingerprint of the Hookworm Necator americanus 2025-03-19 · 01:00

David I. Pritchard – guest , Veeren M Chauhan – curator/researcher @ University of Nottingham , David J. Scurr – guest , Jonathan W. Aylott – guest , Gary Telford – guest , Thomas Christie – guest

How does a tiny hookworm outsmart the human immune system? In this episode, we explore the physicochemical fingerprint of Necator americanus, a parasite that infects millions worldwide. Using cutting-edge techniques like atomic force microscopy (AFM) and time-of-flight secondary ion mass spectrometry (ToF-SIMS), researchers reveal how the hookworm’s sheath and cuticle surfaces play a crucial role in immune evasion and infection.

🔍 Key Topics Covered: • The unique surface properties of N. americanus at the infective L3 stage • How the hookworm’s sheath diverts immune defences, aiding reinfection • The role of nano-annuli in enhancing adhesion and survival • How surface chemistry, including heparan sulphate and phosphatidylglycerol, influences parasite migration

📖 Based on the research article: “The Physicochemical Fingerprint of Necator americanus”** Veeren M. Chauhan, David J. Scurr, Thomas Christie, Gary Telford, Jonathan W. Aylott, David I. Pritchard. Published in PLOS Neglected Tropical Diseases (2017). 🔗 Read it here: https://doi.org/10.1371/journal.pntd.0005971

Join us as we discuss how surface biochemistry influences parasite survival, reinfection, and potential future treatments!

🎧 Subscribe to the WoRM Podcast for more deep dives into cutting-edge parasitology research!

This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch.

📩 More info: 🔗 www.veerenchauhan.com 📧 [email protected]

AI/ML

EPISODE 4: Magic Nanosensors Reveal Intestinal pH Oscillations in C. elegans 2025-03-12 · 01:00

David I. Pritchard – guest , Veeren M Chauhan – curator/researcher @ University of Nottingham , Jonathan W. Aylott – guest , Alan Brown – guest , Gianni Orsi – guest

Did you know that digestion in C. elegans follows a rhythmic pH cycle? In this episode, we explore how magic nanosensors uncover real-time intestinal pH oscillations inside these tiny nematodes. By mapping the gut’s acidic landscape, researchers reveal how proton pumps, digestion, and metabolism work together in a synchronised chemical dance—offering new insights for biomedicine and drug discovery.

🔍 Key Topics Covered: • How pH-sensitive nanosensors track acidity in living organisms • The real-time pH oscillations inside the C. elegans gut • The role of proton pumps and metabolism in digestion • How this discovery could impact gut health and biomedical research

📖 Based on the research article: “Mapping the Pharyngeal and Intestinal pH of Caenorhabditis elegans and Real-Time Luminal pH Oscillations Using Extended Dynamic Range pH-Sensitive Nanosensors” Veeren M. Chauhan, Gianni Orsi, Alan Brown, David I. Pritchard, Jonathan W. Aylott. Published in ACS Nano (2013). 🔗 Read it here: https://doi.org/10.1021/nn401856u

Join us as we uncover how pH-shifting nanosensors are revolutionising our understanding of digestion and metabolism!

🎧 Subscribe to the WoRM Podcast for more deep dives into frontier science!

This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch.

📩 More info: 🔗 www.veerenchauhan.com 📧 [email protected]

AI/ML

EPISODE 3: The Hidden Mechanical Properties of Biological Surfaces – Brillouin Endo-Microscopy 2025-03-05 · 01:00

Veeren M Chauhan – curator/researcher @ University of Nottingham , Salvatore La Cavera III – guest

In this episode, we uncover a revolutionary approach to imaging the hidden mechanical properties of biological surfaces using Label-Free Brillouin Endo-Microscopy. Unlike traditional imaging techniques that rely on fluorescent labels, this method provides quantitative 3D viscoelastic mapping at the sub-micrometre scale—offering unprecedented insights into biological structures.

🔍 Key Topics Covered: • How Brillouin scattering enables real-time mechanical imaging of living tissue • First-ever 3D stiffness mapping of Caenorhabditis elegans cuticle in situ • Potential applications for non-invasive diagnostics and disease research • The future of elasticity-based biomedical imaging

📖 Based on the research article: “Label-Free Brillouin Endo-Microscopy for the Quantitative 3D Imaging of Sub-Micrometre Biology” Salvatore La Cavera III, Veeren M. Chauhan, et al. Published in Communications Biology (2024). 🔗 Read it here: https://doi.org/10.1038/s42003-024-06126-4

Join us as we explore how this breakthrough could transform biomedical imaging, mechanobiology, and in vivo diagnostics!

🎧 Subscribe to the WoRM Podcast for more deep dives into groundbreaking research!

This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch.

📩 More info: 🔗 www.veerenchauhan.com 📧 [email protected]

AI/ML

EPISODE 1: Nematode Surface Lipids: Development, Species Adaptations, and Interactions 2025-02-21 · 11:32

Veeren M Chauhan – curator/researcher @ University of Nottingham

Surface Lipids in Nematodes are Influenced by Development and Species-specific Adaptations

This research utilizes 3D-OrbiSIMS to analyze the surface lipids of nematodes, specifically Caenorhabditis elegans and Pristionchus pacificus, revealing their complex chemical compositions. Surface lipids are found to be developmentally dependent and species-specific, highlighting evolutionary adaptations. The study identifies that the peroxisomal β-oxidation pathway, particularly the enzyme DAF-22, is crucial for defining the surface molecular fingerprint and lipid metabolism. Furthermore, altered surface lipid composition in daf-22 mutants increases their susceptibility to predation, demonstrating the role of surface lipids in interspecies interactions and defense mechanisms. These findings enhance our understanding of nematode surface chemistry and its influence on behavior and survival.2025 AM Kotowska, F Hiramatsu, MR Alexander, DJ Scurr, JW Lightfoot, Veeren M Chauhan* “Surface Lipids in Nematodes are Influenced by Development and Species-specific Adaptations” JACShttps://pubs.acs.org/doi/10.1021/jacs.4c12519 This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch.

📩 More info: 🔗 www.veerenchauhan.com 📧 [email protected]

AI/ML

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