Rydberg atoms offer unique quantum properties that enable radio-frequency sensing capabilities distinct from any classical analogue; however, large parameter spaces and complex configurations make understanding and designing these quantum experiments challenging. Current solutions are often developed as in-house, closed-sourced software simulating a narrow range of problems. We present RydIQule, an open-source package leveraging tools of computational python in novel ways to model the behavior of these systems generally. We describe RydIQule’s approach to representing quantum systems using computational graphs and leveraging numpy broadcasting to define complete experiments. In addition to discussing the computational challenges RydIQule helps overcome, we outline how collaboration between physics and computational research backgrounds has led to this impactful tool.