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In this episode, we travel back to one of the great origin stories in gene regulation: the discovery of lin-4, the first-ever microRNA. In Caenorhabditis elegans, scientists found that tiny non-coding RNAs could silence gene expression by pairing with target mRNAs — launching the entire field of microRNA biology. We explore: How lin-4 regulates developmental timing by repressing LIN-14 protein The discovery of small RNAs (22 and 61 nucleotides) as gene regulators The first evidence for RNA-RNA antisense interactions controlling translation Why this work reshaped our understanding of gene expression across species How a worm taught us that not all genes code for proteins 📖 Based on the research article: "The C. elegans Heterochronic Gene lin-4 Encodes Small RNAs with Antisense Complementarity to lin-14" Rosalind C. Lee, Rhonda L. Feinbaum & Victor Ambros. Published in Cell (1993). 🔗 https://doi.org/10.1016/0092-8674(93)90529-Y 🎧 Subscribe to the WOrM Podcast for more whole-organism breakthroughs that reshaped biology!

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With the rapid rise of graph databases, organizations are now implementing advanced analytics and machine learning solutions to help drive business outcomes. This practical guide shows data scientists, data engineers, architects, and business analysts how to get started with a graph database using TigerGraph, one of the leading graph database models available. You'll explore a three-stage approach to deriving value from connected data: connect, analyze, and learn. Victor Lee, Phuc Kien Nguyen, and Alexander Thomas present real use cases covering several contemporary business needs. By diving into hands-on exercises using TigerGraph Cloud, you'll quickly become proficient at designing and managing advanced analytics and machine learning solutions for your organization. Use graph thinking to connect, analyze, and learn from data for advanced analytics and machine learning Learn how graph analytics and machine learning can deliver key business insights and outcomes Use five core categories of graph algorithms to drive advanced analytics and machine learning Deliver a real-time 360-degree view of core business entities, including customer, product, service, supplier, and citizen Discover insights from connected data through machine learning and advanced analytics