Traces the evolution of data use in clinical practice from real-time patient data collection and interpretation to precision medicine and real-time clinical decision support. Discusses the development of biostatistics, randomized controlled trials, meta-analyses, and the impact of big data and generative AI on the future patient–doctor relationship and healthcare.

Overview of large-scale genomic studies powered by high-throughput sequencing and genotyping to catalog genetic variants underpinning human disease risk. Uses Polygenic Scores to quantify predisposition and stratify individuals for precision medicine, enabling tailored treatments and facilitating the discovery of therapeutic targets by linking variant associations to functional pathways.