This handbook provides a state-of-the-art overview of the analysis of large-scale datasets. Featuring contributions from statistics and computer science experts in industry and academia, the text instills a working understanding of key statistical and computing ideas that can be readily applied in research and practice. Offering balanced coverage of methodology, theory, and applications, the text describes modern, scalable approaches for analyzing large datasets. It details advances in statistics and machine learning, as well as defines the underlying concepts of the available analytical tools and techniques.