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Can a tiny dose of caffeine help a worm live longer? In this episode, we explore how C. elegans responds to the world’s favourite stimulant. Researchers show that low-dose caffeine extends lifespan, while higher doses flip into toxicity — revealing a fine balance between metabolic stress, development, and purinergic signalling.

We cover: How small amounts of caffeine boost survival in C. elegans Why high doses shorten lifespan and slow development Effects on growth, body size, and reproduction How adenosine signalling partially controls caffeine’s impact Why the DAF-2 insulin/IGF-1 pathway is required for the longevity effect What this teaches us about conserved stimulant–ageing biology It’s the worm equivalent of a perfectly measured flat white — just enough buzz to help you thrive.

Based on the research article: “Lifespan Extension Induced by Caffeine in Caenorhabditis elegans is Partially Dependent on Adenosine Signaling” José C. Bridi, Arthur G.A. Barros, Laura R. Sampaio, João C.D. Ferreira, Fabiano A. Antunes Soares & Marcos A. Romano-Silva. Frontiers in Aging Neuroscience (2015) 🔗 https://doi.org/10.3389/fnagi.2015.00220

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This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch.

📩 More info: 🔗 ⁠⁠www.veerenchauhan.com⁠⁠ 📧 [email protected]

Centralize, harmonize, and streamline. That’s how Roche delivers self-service analytics to the thousands of people in its pharma commercial sector. Dbt is powering the backend solution that combines over 60 transactional systems into a harmonized simplified data model. By adopting a version-controlled approach and enabling end-to-end lineage tracking, we achieved significant reduction in duplication and accelerated time-to-insight for data-driven decision-making. The transition from a heterogeneous technology stack to standardized ways of working has fostered greater flexibility in allocating resources across the organization to address diverse use cases. Additionally, the scalable nature of this platform allows us to easily replicate successful data solutions globally. We further augmented our capabilities by integrating generative AI into our Redshift data warehouse, empowering the creation of innovative data products using dbt. This presentation will share practical lessons learned, architectural insights, and the tangible business impact realized from this data platform modernization.

Speaker: João Antunes Lead Engineer Hoffmann-La Roche

Read the blog to learn about the latest dbt Cloud features announced at Coalesce, designed to help organizations embrace analytics best practices at scale https://www.getdbt.com/blog/coalesce-2024-product-announcements