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In this episode, we dive into a new version of WormGazer as described in a recent GeroScience paper. This implementation automates movement monitoring in C. elegans populations as a rapid healthspan measure, offering a shortcut to detect ageing interventions and trade-offs.

Highlights include: • Monitoring multiple Petri dishes in parallel with cameras and image analysis over 7–14 days  • Showing that most functional decline happens in the first week of adulthood  • Validating with age-1(hx546) mutants, which remain active longer but move more slowly early on  • A dose-response test with sulfamethoxazole (SMX) where movement improvements are detectable within 7 days, compared to 40 days needed for traditional lifespan assays  • The benefit: non-invasive, scalable, and faster detection of ageing effects and negative trade-offs 

📖 Based on the research article: “Rapid measurement of ageing by automated monitoring of movement of C. elegans populations”

Giulia Zavagno, Adelaide Raimundo, Andy Kirby, Christopher Saunter & David Weinkove Published in GeroScience (November 2023) 

🔗 https://doi.org/10.1007/s11357-023-00998-w 

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This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch.

📩 More info: 🔗 ⁠⁠www.veerenchauhan.com⁠⁠ 📧 [email protected]

This week Peter will present ClimSim: A large multi-scale dataset for hybrid physics-ML climate emulation by Sungduk Yu · Walter Hannah · Liran Peng · Jerry Lin · Mohamed Aziz Bhouri · Ritwik Gupta · Björn Lütjens · Justus C. Will · Gunnar Behrens · Julius Busecke · Nora Loose · Charles Stern · Tom Beucler · Bryce Harrop · Benjamin Hillman · Andrea Jenney · Savannah L. Ferretti · Nana Liu · Animashree Anandkumar · Noah Brenowitz · Veronika Eyring · Nicholas Geneva · Pierre Gentine · Stephan Mandt · Jaideep Pathak · Akshay Subramaniam · Carl Vondrick · Rose Yu · Laure Zanna · Tian Zheng · Ryan Abernathey · Fiaz Ahmed · David Bader · Pierre Baldi · Elizabeth Barnes · Christopher Bretherton · Peter Caldwell · Wayne Chuang · Yilun Han · YU HUANG · Fernando Iglesias-Suarez · Sanket Jantre · Karthik Kashinath · Marat Khairoutdinov · Thorsten Kurth · Nicholas Lutsko · Po-Lun Ma · Griffin Mooers · J. David Neelin · David Randall · Sara Shamekh · Mark Taylor · Nathan Urban · Janni Yuval · Guang Zhang · Mike Pritchard.

We look forward to seeing you there!

Want to know more Paper Club?

• We discuss a different research paper every week. We post each week's paper in our GitHub repo - please read it before the meetup.
• All events will be hosted on a Google Meets video call. Once a month we also host an in-person event in our London office - watch this space for updates.
• All recorded presentations can be found in our YouTube channel (don't forget to subscribe!).

This week Gerard will be presenting Sleeper Agents: Training Deceptive LLMs that Persist Through Safety Training By Evan Hubinger, Carson Denison, Jesse Mu, Mike Lambert, Meg Tong, Monte MacDiarmid, Tamera Lanham, Daniel M. Ziegler, Tim Maxwell, Newton Cheng, Adam Jermyn, Amanda Askell, Ansh Radhakrishnan, Cem Anil, David Duvenaud, Deep Ganguli, Fazl Barez, Jack Clark, Kamal Ndousse, Kshitij Sachan, Michael Sellitto, Mrinank Sharma, Nova DasSarma, Roger Grosse, Shauna Kravec, Yuntao Bai, Zachary Witten, Marina Favaro, Jan Brauner, Holden Karnofsky, Paul Christiano, Samuel R. Bowman, Logan Graham, Jared Kaplan, Sören Mindermann, Ryan Greenblatt, Buck Shlegeris, Nicholas Schiefer, Ethan Perez.

All events will be hosted on a Google Meets video call. Once a month we also host an in-person event in our London office - watch this space for updates.

All recorded presentations can be found in our YouTube channel (don't forget to subscribe!).

We look forward to seeing you there!

This week our guest speaker Ben Boys will be presenting Photorealistic Text-to-Image Diffusion Models with Deep Language Understanding by Chitwan Saharia, William Chan, Saurabh Saxena, Lala Li, Jay Whang, Emily Denton, Seyed Kamyar Seyed Ghasemipour, Burcu Karagol Ayan, S. Sara Mahdavi, Rapha Gontijo Lopes, Tim Salimans, Jonathan Ho, David J Fleet, Mohammad Norouzi.

For the purpose of a more in depth discussion on the day, please read the paper ahead of time. We look forward to seeing you all there!

We discuss a different research paper every week. We post each week's paper in our GitHub repo - please read it before the meetup.

All events will be hosted on a Google Meets video call. Once a month we also host an in-person event in our London office - watch this space for updates.

All recorded presentations can be found in our YouTube channel (don't forget to subscribe!).

This is our interview with Dorje Brody about his recent paper with David Meier, How to model fake news. This paper uses the tools of communication theory and a sub-topic called filtering theory to describe the mathematical basis for an information channel which can contain fake news.   Thanks to our sponsor Gartner.

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