An essential guide to the concepts of probability theory that puts the focus on models and applications Introduction to Probability offers an authoritative text that presents the main ideas and concepts, as well as the theoretical background, models, and applications of probability. The authors—noted experts in the field—include a review of problems where probabilistic models naturally arise, and discuss the methodology to tackle these problems. A wide-range of topics are covered that include the concepts of probability and conditional probability, univariate discrete distributions, univariate continuous distributions, along with a detailed presentation of the most important probability distributions used in practice, with their main properties and applications. Designed as a useful guide, the text contains theory of probability, de finitions, charts, examples with solutions, illustrations, self-assessment exercises, computational exercises, problems and a glossary. This important text: • Includes classroom-tested problems and solutions to probability exercises • Highlights real-world exercises designed to make clear the concepts presented • Uses Mathematica software to illustrate the text’s computer exercises • Features applications representing worldwide situations and processes • Offers two types of self-assessment exercises at the end of each chapter, so that students may review the material in that chapter and monitor their progress. Written for students majoring in statistics, engineering, operations research, computer science, physics, and mathematics, Introduction to Probability: Models and Applications is an accessible text that explores the basic concepts of probability and includes detailed information on models and applications.

Reliability Modelling and Analysis in Discrete Time provides an overview of the probabilistic and statistical aspects connected with discrete reliability systems. This engaging book discusses their distributional properties and dependence structures before exploring various orderings associated between different reliability structures. Though clear explanations, multiple examples, and exhaustive coverage of the basic and advanced topics of research in this area, the work gives the reader a thorough understanding of the theory and concepts associated with discrete models and reliability structures. A comprehensive bibliography assists readers who are interested in further research and understanding. Requiring only an introductory understanding of statistics, this book offers valuable insight and coverage for students and researchers in Probability and Statistics, Electrical Engineering, and Reliability/Quality Engineering. The book also includes a comprehensive bibliography to assist readers seeking to delve deeper. Includes a valuable introduction to Reliability Theory before covering advanced topics of research and real world applications Features an emphasis on the mathematical theory of reliability modeling Provides many illustrative examples to foster reader understanding

Methods and Applications of Statistics in Clinical Trials, Volume 2: Planning, Analysis, and Inferential Methods includes updates of established literature from the Wiley Encyclopedia of Clinical Trials as well as original material based on the latest developments in clinical trials. Prepared by a leading expert, the second volume includes numerous contributions from current prominent experts in the field of medical research. In addition, the volume features: Multiple new articles exploring emerging topics, such as evaluation methods with threshold, empirical likelihood methods, nonparametric ROC analysis, over- and under-dispersed models, and multi-armed bandit problems Up-to-date research on the Cox proportional hazard model, frailty models, trial reports, intrarater reliability, conditional power, and the kappa index Key qualitative issues including cost-effectiveness analysis, publication bias, and regulatory issues, which are crucial to the planning and data management of clinical trials

A complete guide to the key statistical concepts essential for the design and construction of clinical trials As the newest major resource in the field of medical research, Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs presents a timely and authoritative reviewof the central statistical concepts used to build clinical trials that obtain the best results. The referenceunveils modern approaches vital to understanding, creating, and evaluating data obtained throughoutthe various stages of clinical trial design and analysis. Accessible and comprehensive, the first volume in a two-part set includes newly-written articles as well as established literature from the Wiley Encyclopedia of Clinical Trials. Illustrating a variety of statistical concepts and principles such as longitudinal data, missing data, covariates, biased-coin randomization, repeated measurements, and simple randomization, the book also provides in-depth coverage of the various trial designs found within phase I-IV trials. Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs also features: Detailed chapters on the type of trial designs, such as adaptive, crossover, group-randomized, multicenter, non-inferiority, non-randomized, open-labeled, preference, prevention, and superiority trials Over 100 contributions from leading academics, researchers, and practitioners An exploration of ongoing, cutting-edge clinical trials on early cancer and heart disease, mother-to-child human immunodeficiency virus transmission trials, and the AIDS Clinical Trials Group Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs is an excellent reference for researchers, practitioners, and students in the fields of clinicaltrials, pharmaceutics, biostatistics, medical research design, biology, biomedicine, epidemiology,and public health.

Chi-Squared Goodness of Fit Tests with Applications provides a thorough and complete context for the theoretical basis and implementation of Pearson’s monumental contribution and its wide applicability for chi-squared goodness of fit tests. The book is ideal for researchers and scientists conducting statistical analysis in processing of experimental data as well as to students and practitioners with a good mathematical background who use statistical methods. The historical context, especially Chapter 7, provides great insight into importance of this subject with an authoritative author team. This reference includes the most recent application developments in using these methods and models. Systematic presentation with interesting historical context and coverage of the fundamentals of the subject Presents modern model validity methods, graphical techniques, and computer-intensive methods Recent research and a variety of open problems Interesting real-life examples for practitioners