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In this talk, Sebastian, a bioinformatics researcher and software engineer, shares his inspiring journey from wet lab biotechnology to computational bioinformatics. Hosted by Data Talks Club, this session explores how data science, AI, and open-source tools are transforming modern biological research — from DNA sequencing to metagenomics and protein structure prediction.

You’ll learn about: - The difference between wet lab and dry lab workflows in biotechnology - How bioinformatics enables faster insights through data-driven modeling - The MCW2 Graph Project and its role in studying wastewater microbiomes - Using co-abundance networks and the CC Lasso algorithm to map microbial interactions - How AlphaFold revolutionized protein structure prediction - Building scientific knowledge graphs to integrate biological metadata - Open-source tools like VueGen and VueCore for automating reports and visualizations - The growing impact of AI and large language models (LLMs) in research and documentation - Key differences between R (BioConductor) and Python ecosystems for bioinformatics

This talk is ideal for data scientists, bioinformaticians, biotech researchers, and AI enthusiasts who want to understand how data science, AI, and biology intersect. Whether you work in genomics, computational biology, or scientific software, you’ll gain insights into real-world tools and workflows shaping the future of bioinformatics.

Links: - MicW2Graph: https://zenodo.org/records/12507444 - VueGen: https://github.com/Multiomics-Analytics-Group/vuegen - Awesome-Bioinformatics: https://github.com/danielecook/Awesome-Bioinformatics

TIMECODES00:00 Sebastian’s Journey into Bioinformatics06:02 From Wet Lab to Computational Biology08:23 Wet Lab vs Dry Lab Explained12:35 Bioinformatics as Data Science for Biology15:30 How DNA Sequencing Works19:29 MCW2 Graph and Wastewater Microbiomes23:10 Building Microbial Networks with CC Lasso26:54 Protein–Ligand Simulation Basics29:58 Predicting Protein Folding in 3D33:30 AlphaFold Revolution in Protein Prediction36:45 Inside the MCW2 Knowledge Graph39:54 VueGen: Automating Scientific Reports43:56 VueCore: Visualizing OMIX Data47:50 Using AI and LLMs in Bioinformatics50:25 R vs Python in Bioinformatics Tools53:17 Closing Thoughts from Ecuador Connect with Sebastian Twitter - https://twitter.com/sayalaruanoLinkedin - https://linkedin.com/in/sayalaruano Github - https://github.com/sayalaruanoWebsite - https://sayalaruano.github.io/ Connect with DataTalks.Club: Join the community - https://datatalks.club/slack.htmlSubscribe to our Google calendar to have all our events in your calendar - https://calendar.google.com/calendar/r?cid=ZjhxaWRqbnEwamhzY3A4ODA5azFlZ2hzNjBAZ3JvdXAuY2FsZW5kYXIuZ29vZ2xlLmNvbQCheck other upcoming events - https://lu.ma/dtc-eventsGitHub: https://github.com/DataTalksClubLinkedIn - https://www.linkedin.com/company/datatalks-club/Twitter - https://twitter.com/DataTalksClub - Website - https://datatalks.club/

We plan to cover: Transitioning from biotechnology to computational work; Building and maintaining open-source bioinformatics tools; The challenges and opportunities of multi-omics data analysis; Advice for life science students interested in programming and bioinformatics.

An accessible guide that introduces students in all areas of life sciences to bioinformatics Basic Applied Bioinformatics provides a practical guidance in bioinformatics and helps students to optimize parameters for data analysis and then to draw accurate conclusions from the results. In addition to parameter optimization, the text will also familiarize students with relevant terminology. Basic Applied Bioinformatics is written as an accessible guide for graduate students studying bioinformatics, biotechnology, and other related sub-disciplines of the life sciences. This accessible text outlines the basics of bioinformatics, including pertinent information such as downloading molecular sequences (nucleotide and protein) from databases; BLAST analyses; primer designing and its quality checking, multiple sequence alignment (global and local using freely available software); phylogenetic tree construction (using UPGMA, NJ, MP, ME, FM algorithm and MEGA7 suite), prediction of protein structures and genome annotation, RNASeq data analyses and identification of differentially expressed genes and similar advanced bioinformatics analyses. The authors Chandra Sekhar Mukhopadhyay, Ratan Kumar Choudhary, and Mir Asif Iquebal are noted experts in the field and have come together to provide an updated information on bioinformatics. Salient features of this book includes: Accessible and updated information on bioinformatics tools A practical step-by-step approach to molecular-data analyses Information pertinent to study a variety of disciplines including biotechnology, zoology, bioinformatics and other related fields Worked examples, glossary terms, problems and solutions Basic Applied Bioinformatics gives students studying bioinformatics, agricultural biotechnology, animal biotechnology, medical biotechnology, microbial biotechnology, and zoology an updated introduction to the growing field of bioinformatics.